- A. Edwin Kendrew Papers, 1930/19591
- Abraham Lincoln Collection, 1860/19651
- Anne and Alan Morledge Collection, 1946/2005, bulk 1969/19881
- Boelt Family Papers, 1948/19751
- Caley Family Papers, 1895/19681
- Carlton Casey Papers, 1894/19991
- Daniel Crump Buchanan Papers, 1935/19571
- Democratic Party Ephemera Collection, 1912/1961, bulk 1912/19281
- Effinger School Collection, 1909/20111
- Ellinor Porcher Gadsden Papers, 1839/19751
- Ephemera Collection, 1800/20141
- Fay Parr Papers, 1920/20021
- Frances Breeze Music Collection, 1890/19801
- Francis P. Gaines Papers, 1803/19791
- Georgia Ragsdale Curtis Papers, 1912/2002, bulk 1930/19751