- Abraham Lincoln Collection, 1860/19651
- Bagby Family Papers, 1854/19011
- Barton Myers Papers, 1878/19251
- Brown Family Papers, 1836/19081
- Caley Family Papers, 1895/19681
- Carlton Casey Papers, 1894/19991
- Charles H. Carson papers, 1800/19001
- Corie Lynn Dorset Rivers Collection of Ludwell-Lee-Slater Family Papers, 1805/19231
- Ellinor Porcher Gadsden Papers, 1839/19751
- Ephemera Collection, 1800/20141
- Frances Breeze Music Collection, 1890/19801
- Francis P. Gaines Papers, 1803/19791
- Hamilton Family Papers, 1892/2003, bulk 1930/20031
- John Turner Henley Papers, 1857/1921, bulk 1918/19211
- Manuscripts - People and Family Names, 1621/1949, bulk 18001