- Brown Family Papers, 1836/19081
- Charles H. Carson papers, 1800/19001
- Corie Lynn Dorset Rivers Collection of Ludwell-Lee-Slater Family Papers, 1805/19231
- Edward C. Dyer Papers, 1848/1865, bulk 1853/18651
- Ellinor Porcher Gadsden Papers, 1839/19751
- Ephemera Collection, 1800/20141
- Francis P. Gaines Papers, 1803/19791
- Helen M. Hoskins papers, 1839/1868, bulk 1845/18601
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Robert E. Lee Family papers, 1792/1935, bulk 1833/18701
- Trice Family Papers, 1830/19201