- Charles Triplett O'Ferrall papers, 1870/18931
- Charles Wilson Turner Collection, 19921
- Christopher Bram Papers, 1968/2014, bulk 1975/20001
- Christopher Wren Singers Records, 1989/2012, bulk 1993/20031
- Cocktail Ephemera Collection1
- Collection of Images Related to Stonewall Jackson, 1861/18751
- Collection of Photographs of Lexington, Va., 1857/19691
- Connie Smith family photograph album, 1950/19801
- Coray S. Brown family photograph collection, 1910/19601
- Crocker Family Postcards, 1900/19301
- Culinary Ephemera Collection1
- Cynthia Barlowe Collection, 1902/20011
- Delphine Hurst Parsons papers, 1923/1976, bulk 1923/19311
- Diary (Eastern United States), 19151
- Doris Ann McFarland Papers
circa 1933-19431