- African American Family Photographs, 1880/19601
- Bettie Hiter Willis Papers, 1864/19421
- Blackley Family papers, 1830/20201
- Carlton Casey Papers, 1894/19991
- Charles Manson Crutchfield Collection of Memorabilia, 1882/1914, bulk 1880/18891
- Charles Page Bryan Papers, 1898/19121
- Charles R. K. Varner collection, 1881/19111
- Charles T. Smith photographs, 1880/2007, bulk 1990/19991
- Collection of Photographs of Lexington, Va., 1857/19691
- Crocker Family Postcards, 1900/19301
- Earl and Jewell Ratliff Collection, 1860/2013, bulk 1920/19901
- Ephemera Collection, 1800/20141
- Franklin Lafayette Riley Papers, 1897/19271
- George M. Neese papers, 1859/19461
- Glidden Family Papers, 1892/1942, bulk 1900/19101