- African American Family Photographs, 1880/19601
- Bettie Hiter Willis Papers, 1864/19421
- Blackley Family papers, 1830/20201
- Charles Manson Crutchfield Collection of Memorabilia, 1882/1914, bulk 1880/18891
- Charles T. Smith photographs, 1880/2007, bulk 1990/19991
- Charles Triplett O'Ferrall papers, 1870/18931
- Collection of Photographs of Lexington, Va., 1857/19691
- Earl and Jewell Ratliff Collection, 1860/2013, bulk 1920/19901
- Ephemera Collection, 1800/20141
- George M. Neese papers, 1859/19461
- Grigsby-Galt Papers, 1736/1982, bulk 1840/19301
- Heatwole Family Papers, 1838/20011
- Henkel Family Papers, 1801/20081
- John Cuthbert, Collector, Historical West Virginia Materials, 1825/19651
- Larry Jones, Collector, Postcards, Photographs, and Other Material, 1785/1993, bulk 1897/19931