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- Samuel Price, Politician, Papers, 1828/18841
- Samuel T. Mallison Papers, 1915/19641
- Scott-Palmer Family Papers, 1829/19161
- Septimius Hall (1847-1926) Papers, 1881/19191
- Septimius Hall Papers, 1871/19121
- Shepherdstown Archives, 1794/19501
- Siler Family Papers, 1848/19681
- Sistersville City Council Minutes, 1846/19551
- Smith Family Papers, 1800/19421
- Socialist Workers Party Papers, 1978/19801
- Stephen Benton Elkins, Letter Copy Book, 1875/18781
- Stephen Jones, Compiler, Senator Chapman Revercomb Research Papers, 1910/2017, bulk 1950/19901