- Dabney Stuart Papers, 1989/2009, bulk 2000/20091
- Davidson Family Papers, 1830/19151
- DisConnect, 20181
- Documenting Life During COVID-19 collection, 20201
- Dorothy Lee Baugher papers, 1936/2003, bulk 1975/19811
- Dr. Robert Goard's Rose Poetry Collection, 2004/20071
- Dr. Sidney Isenberg Collection on Carson McCullers, 1948/19711
- E. P. Conkle papers, 1928/19941
- E. W. Randall Notebook, 18671
- Edward C. Shepherd papers, 1851/18551
- Edward Ferguson Devol Papers, 1940/19461
- Edward H. Peple Collection, 1891/19531
- Ellinor Porcher Gadsden Papers, 1839/19751
- Francis B. Clark collection, 1866/18761
- Frederick L. Torrey Autograph Album, 1838/18431