- Arthur M. Squires Papers, 1888/1987, bulk 1940/19871
- Blacksburg Baptist Church Records, 1894/20071
- Civilian Conservation Corps and Family Photograph Collection, 1925/19361
- Daniel E. Wright Papers, 1903/19731
- Duncan Alexander MacLeod Collection, 1932/19861
- Earl Palmer Appalachian Photograph and Artifact Collection, 1880/19891
- Eleanore Pettersen Architectural Collection, 1915/2003, bulk 1950/20001
- Harry Downing Temple, Jr., Papers, 1872/2004, bulk 1930/20011
- Huddle Family Papers, 1854/19831
- Huron, Ohio, Railroad Construction Photographs, 1912/19371
- Lilia Sofer Skala Student Portfolio, 1915/2003, bulk 1915/19281
- Lucy Lee Lancaster Papers, 1915/19891
- Preston Leech Glass Slides and Cassette Tape, 1900/19941
- Robert Edward Minshall Papers, 1909/19431
- S. Maria Elliott Family Collection, 1826/19421