- Charles Edward Gary, Jr. Papers, 1870/2000, bulk 1940/19801
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/19961
- Charles Grattan Price Jr. collection on Tweetsie and the Shenandoah Central Railroad, 1916/1997, bulk 1948/19561
- Charles J. Duke, Jr. Papers, 1919/19581
- Charles T. Smith photographs, 1880/2007, bulk 1990/19991
- Charles and William Person Papers, 1900/2011, bulk 1920/19501
- Christian-Charles Family Photographs, 1923/19521
- Civilian Conservation Corps and Family Photograph Collection,, 1925/19361
- Clara L. Lawrence Papers, 1763/19391
- Clarence J. Robinson papers, 1897/19781
- Class of 1913 Reunion Book, 1914/19351
- College of Visual and Performing Arts records, 1930/20151
- Colonial Echo records, 1931/20041
- Cynthia Barlowe Collection, 1902/20011
- Cynthia Barlowe and Raymond Kimbrough Collection, 1909/19661