- 19th Century Virginia albumen photographs, 1880/18991
- Abolitionist Movement Collection, 1834/18881
- African American Family Photographs, 1880/19601
- Alexander Haight family collection, 1764/19761
- Alexander Lockhart Nelson papers, 1848/19021
- Amos Koontz Papers I, 1809/1965, bulk 1936/19651
- Anatole and Vladimir Kalichevsky Papers, 1871/19551
- Anderson Family papers, 1755/19581
- Augustus C. Golding Papers, 1859/1934, bulk 1862/18641
- Barbara Cary Johnston Willard Scrapbook, 1800/20061
- Barton Myers Papers, 1878/19251
- Blackley Family papers, 1830/20201
- Bland Family papers, 1778/19891
- Bright Family Papers, 1876/19331
- Broome Family Papers, 1862/19951