- Grove Family Papers, 1884/19321
- Helen L. Johnson Papers, 1925/1982, bulk 1925/19401
- Historic ephemera collection, 1796/19861
- Janet C. Kimbrough Williamsburg Area History Collection, 1873/19941
- Jennings C. Wise papers, 1910/19601
- John Lesslie Hall, Jr. Papers, 1893/19731
- John Tyler, Jr. Papers, 1800/19281
- Julia W. Oxrieder Papers, 1877/19981
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Margaret Grattan Weaver collection, 1707/1992, bulk 1857/19101
- Military & Wartime Cookery Collection, 1884/1965, bulk 1917/19451
- Morecock Collection, 1881/19371
- Rev. Samuel Huntting Sayre, Jr. Papers, 1874/1989, bulk 1920/19601
- Robert E. Lee Family papers, 1792/1935, bulk 1833/18701
- Robert James Sullivan Jr. papers, 1920/20131