- Bland Family papers, 1778/19891
- Charles Campbell Papers, 1743/18961
- Chester McNerney Collection, 1290/19501
- Historic ephemera collection, 1796/19861
- History of the Case of the Commonwealth vs. Lee and Burwell Reynolds, 1800/18801
- Jay W. Johns Jr. Collection of James Monroe Papers, 1780/18341
- John Tyler, Jr. Papers, 1800/19281
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Margaret Grattan Weaver collection, 1707/1992, bulk 1857/19101
- Robert E. Lee Family papers, 1792/1935, bulk 1833/18701
- Virginia Counties Collection, 1600/2000, bulk 1730/18901