- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19744
- A.S. Hammack papers, 1864/19541
- Alfred R. Armstrong Papers, 1928/19761
- Association for the Preservation of Virginia Antiquities, Yorktown Branch Records, 1921/2013, bulk 1975/20051
- Campbell and Varner family papers, 1845/19281
- Charles H. Bell Papers, 1772/1929, bulk 1852/18751
- Collection of W. W. Yen materials, 1899/19741
- Davis, Kline, and Hutton Family papers, 1816/19771
- Edwin S. Cohen papers, 1924/1995, bulk 1946/19891
- Eleanor Calkins Papers, 1915/1961, bulk 1927/19611
- Elizabeth Winston Lanier Papers, 1926/1988, bulk 1975/19881
- Ephemera Collection, 1800/20141
- Fairfax Harrison Papers, 1736/19451
- George S. Patton compositions, 1904/19451
- Grace Warren Landrum Papers, 1890/19951