- A.S. Hammack papers, 1864/19541
- Baird Family Papers, 1656/1922, bulk 1656/18481
- Campbell and Varner family papers, 1845/19281
- Charles H. Bell Papers, 1772/1929, bulk 1852/18751
- Collection of W. W. Yen materials, 1899/19741
- Davis, Kline, and Hutton Family papers, 1816/19771
- Eleanor Calkins Papers, 1915/1961, bulk 1927/19611
- Elizabeth Van Lew Collection, 1854/19261
- Ephemera Collection, 1800/20141
- Fairfax Harrison Papers, 1736/19451
- George S. Patton compositions, 1904/19451
- Grace Warren Landrum Papers, 1890/19951
- Gray G. Holloway Surgeon's Case Book, 1896/19241
- Guy Family Papers, 1900/19881
- Hall Family Papers, 1810/20071