- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19745
- A.S. Hammack papers, 1864/19541
- Baird Family Papers, 1656/1922, bulk 1656/18481
- Bessie M. Rhoades botany workbook and notebooks, 1903/19041
- Campbell and Varner family papers, 1845/19281
- Charles H. Bell Papers, 1772/1929, bulk 1852/18751
- Collection of W. W. Yen materials, 1899/19741
- Copp's Schoolhouse Notebook and Ledger, 1867/19081
- Davis, Kline, and Hutton Family papers, 1816/19771
- Elizabeth Van Lew Collection, 1854/19261
- Ephemera Collection, 1800/20141
- Fairfax Harrison Papers, 1736/19451
- Galt Papers (III-A), 1848/19171
- Grace Warren Landrum Papers, 1890/19951
- Gray G. Holloway Surgeon's Case Book, 1896/19241