- James M. Owens Collection of Madison Family Material, 1776/19531
- John Womack Wright Collection of Maps, 1675/19181
- Lee Nicholson Papers, 1827/19381
- Marie M. and Edith W. Smith Papers, 1783/18621
- Mary and Hannah Gibbons Papers, 1743/18901
- Moncure Robinson Papers, 1787/18891
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19741
- Physician's Notebook and Household Remedies, 1820/18401
- Ralph Green Papers, circa 1858-1960, 1813/18581
- Robertson Family Papers, 1730/19501
- Robinson Family Papers, 1725/1940, bulk 1793/18481
- Thomas Jefferson Stubbs Family Papers, 1789/19331
- Tyler Family Papers, Group H, 1750/19351
- University Archives Bound Volumes Collection, 1693/19931
- Upshur Family Papers, 1662/19361