- James R. Perdue Family Collection, 1868/19191
- James Tarter Ledgers, 1879/19411
- John C. Wysor Letter, 19121
- John Harville Diaries, 1861/2010, bulk 1861/18641
- John Shaw Billings Letters, 18801
- Leonard A. Slater Letter, 18621
- Linwood D. Keyser Papers, 1889/19441
- Mason County Medical Doctors Index1
- Maupin-Washington Papers, 1732/19321
- Meade & Baker Apothecary Ledger, 1861/18701
- Medical Bill Signed by Dr. Harvey Black, 1865/18791
- Medical Text1
- Medical slides collection, 1980/19892
- Pepto medicine bottle1
- Piedmont Tuberculosis Sanatorium (Burkeville, Virginia) Collection, 1926/19711