- Milka T. Bliznakov Papers and Architectural Drawings, 1946/20101
- New River Community Action, Inc., Records, 1966/20151
- Newport and Clover Hollow, Giles County History Collection, 1904/20061
- Organ Family Collection, 1836/20061
- Peacock-Harper Culinary History Friends Records, 1999/20191
- Records of the American Association of University Women (AAUW), Virginia Tech Chapter, 1926/20081
- Rick Boucher Papers, 1968/2017, bulk 1975/20111
- Roanoke Appalachian Trail Club Records, 20251
- Roanoke Valley Academy of Medicine Records, 1874/20161
- Robert Creede Taylor Family Reference Collection, 2003/20061
- Southside Garden Club Records, 1914/20091
- The Reverend Dr. and Mrs. Richard Eugene Hager (Anne Peyton Judkins Hager) Collection, 1802/20071
- Thomas David Perry Collection, 1979/20071
- United Daughters of the Confederacy, Dr. Harvy Black Chapter Records, 1862/20101
- Virginia Association of Educational Opportunity Program Personnel (VAEOPP) Records, 1970/20151