- A. J. Davis Family Collection, 1874/2007, bulk 1874/19071
- Alleghany Chapter, National Society of the Daughters of the American Revolution Records, 1890/20221
- Appalachian Regional Commission Teaching Project Records, 2001/20061
- Benjamin Huddle Diary, 1861/20061
- Blacksburg Baptist Church Records, 1894/20071
- Blacksburg Electronic Village Collection, 1992/20061
- Carter/Cash Family Collection, 1940/20091
- Elizabeth Fine Papers, 1983/20121
- Hard Times Blues Collection, 1966/20191
- J. Hoge Tyler Diary, 1846/2009, bulk 1846/19251
- John M. and Cora Bolton McBryde Family Papers, 1862/20181
- Lucy Herndon Crockett Papers, 1940/20151
- Lyric Theatre Collection, 1922/2006, bulk 1922/19791
- Madison E. Marye Papers, 1932/20071
- Margaret M. Sullivan Collection, 1932/20111