- A. J. Davis Family Collection, 1874/2007, bulk 1874/19071
- Alleghany Chapter, National Society of the Daughters of the American Revolution Records,, 1890/20221
- An Historical Map of Roanoke County, Virginia (from The Roanoke Times), 19681
- An Historical Map of Roanoke County, Virginia, 19681
- Anna Whitehead Kenney Papers, 1965/19721
- Anne H. Price Yates Papers, 1904/1985, bulk 1975/19851
- Anne Price Yates Papers II, 1898/20051
- Association for the Preservation of Virginia Antiquities, Montgomery County Branch Papers, 1754/1996, bulk 1958/19831
- Bell, Kent, Cloyd, Withrow Family Collection, 1780/19981
- Benjamin Huddle Diary, 1861/20061
- Beulah O. Allen Collection,, 1905/1992, bulk 1920/19701
- Bishop William H. Marmion Papers, 1932/19811
- Black, Kent, and Apperson Family Papers, 1779/19841
- Blacksburg Baptist Church Records, 1894/20071
- Blacksburg Chamber Music Series Collection, 1967/19821