- Alexander McNutt Glasgow Family Papers, 1823/19031
- Anna Burton Ellett Collection, 1751/19321
- Argabright Family Ledger, 1848/18541
- Association for the Preservation of Virginia Antiquities, Montgomery County Branch Papers, 1754/1996, bulk 1958/19831
- Barclay Shipping Ledger, 1847/18781
- Bear Family Papers, 1823/18791
- Bell, Kent, Cloyd, Withrow Family Collection, 1780/19981
- Bigler-Sessler-John Family Papers, 1752/19251
- Black, Kent, and Apperson Family Papers, 1779/19841
- Blacksburg [Virginia] Presbyterian Church Land Deeds, 1850/19241
- Bobbitt Family Papers, 1825/19511
- Bristol-Moore Stamp Kit, 1854/18631
- Brown Family Papers, 1825/1965, bulk 1850/18941
- Charles A. Miller Family Papers, 1708/19261
- Charles W. Crush Collection, 1796/19781