- Adele Blow Chatfield-Taylor family papers, 1899/19771
- Allen-Kean-Laurence family letters, 1837/19601
- Alumni Association Records, 1924/20161
- American Association of University Women (AAUW) Records, Harrisonburg, Virginia Branch, 1929/20251
- Audie Scott Tilghman papers, 1925/19301
- Barnhart Family Papers, 1836/19441
- Bettie Hiter Willis Papers, 1864/19421
- Betty Brown Clemmer and Willis Clemmer papers, 1920/2015, bulk 1943/19491
- Blackley Family papers, 1830/20201
- Bosworth and Fling Family Papers, 1890/1960, bulk 1935/19571
- Bristow Family Papers, 1900/1973, bulk 1962/19671
- Caley Family Papers, 1895/19681
- Captain Jimmie Slosson letters, 1925/19571
- Catlett Family Papers, 1850/1933, bulk 1901/19291
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/19961