- Alumni Association Records, 1924/20161
- Audie Scott Tilghman papers, 1925/19301
- Barnhart Family Papers, 1836/19441
- Bertha Couchman Hess and Ethel Virginia Dunn Correspondence, 1918/19271
- Bettie Hiter Willis Papers, 1864/19421
- Betty Brown Clemmer and Willis Clemmer papers, 1920/2015, bulk 1943/19491
- Blackley Family papers, 1830/20201
- Catlett Family Papers, 1850/1933, bulk 1901/19291
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/19961
- Charles Grattan Price Jr. collection on Tweetsie and the Shenandoah Central Railroad, 1916/1997, bulk 1948/19561
- Chesapeake Western Railway Company Records, 1916/19821
- Christine Hoepfner Collection on the Shenandoah National Park, 1911/20001
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19281
- Daisy Bacon Papers, 1857/19861
- Davis, Kline, and Hutton Family papers, 1816/19771