- Adele Blow Chatfield-Taylor family papers, 1899/19771
- Allen-Kean-Laurence family letters, 1837/19601
- Barnhart Family Papers, 1836/19441
- Barton Myers Papers, 1878/19251
- Bertha Couchman Hess and Ethel Virginia Dunn Correspondence, 1918/19271
- Bettie Hiter Willis Papers, 1864/19421
- Betty Brown Clemmer and Willis Clemmer papers, 1920/2015, bulk 1943/19491
- Blackley Family papers, 1830/20201
- Bosworth and Fling Family Papers, 1890/1960, bulk 1935/19571
- Bristow Family Papers, 1900/1973, bulk 1962/19671
- Caley Family Papers, 1895/19681
- Catlett Family Papers, 1850/1933, bulk 1901/19291
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/19961
- Charles Grattan Price Jr. collection on Tweetsie and the Shenandoah Central Railroad, 1916/1997, bulk 1948/19561
- Charles and William Person Papers, 1900/2011, bulk 1920/19501