- Allen-Kean-Laurence family letters, 1837/19601
- Andrew J. Weeks Papers, 1861/1902, bulk 1862/18661
- Autographs of Virginians, 1846/19081
- Barnhart Family Papers, 1836/19441
- Barton Myers Papers, 1878/19251
- Bettie Hiter Willis Papers, 1864/19421
- Blackley Family papers, 1830/20201
- Booton-Modesitt Family Papers, 1809/1880, bulk 1820/18501
- Brown Family Papers, 1836/19081
- Brown Family papers, 1872/19191
- Catlett Family Papers, 1850/1933, bulk 1901/19291
- Catlett Family Papers, 1865/19211
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/19961
- Charles Spitzer Letters, 1833/18861
- Charles Triplett O'Ferrall papers, 1870/18931