- Allen-Kean-Laurence family letters, 1837/19601
- Andrew J. Weeks Papers, 1861/1902, bulk 1862/18661
- Autographs of Virginians, 1846/19081
- Booton-Modesitt Family Papers, 1809/1880, bulk 1820/18501
- Brown Family Papers, 1836/19081
- Catlett Family Papers, 1865/19211
- Christopher Columbus Collection, 1849/18801
- Clara L. Lawrence Papers, 1763/19391
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Craig Family Papers, 1860/1906, bulk 1860/18801
- Flora Adams Darling papers, 1862/1908, bulk 1890/19081
- Geddy-Harris Archive Records, 1773/1959, bulk 1890/19401
- George Michener Hart Collection on Moncure Robinson, 1816/19191
- George See, Jr. Notebook, 1863/18711
- Grigsby-Galt Papers, 1736/1982, bulk 1840/19301