- Henry Waring Latane Lewis family papers, 1826/18931
- J. W. Hollis to Joseph Funk Letters, 18321
- James Madison Memorabilia, 1796/19511
- John "Jack" Fitzgerald Papers, 1827/18551
- John Randolph The Tory Papers, 1779/1840, bulk 1779/18401
- John T. Harris papers, 1771/1937, bulk 1850/19001
- Liskey Collection of Heavner Family Papers, 1788/19671
- Manley Family papers, 1707/19531
- Margaret B. Burruss Collection of Scott and Saufley Family Papers, 1786/19121
- Margaret Grattan Weaver collection, 1707/1992, bulk 1857/19101
- Mr. and Mrs. James Hoover Collection of Strickler Family Papers, 1770/19631
- Office of the President. Thomas Roderick Dew Records, 1833/18521
- Patricia Turner Ritchie collection on Brocks Gap, 1750/19901
- Pierre Etienne Duponceau papers, 1781/18451
- Richard G. Joynt Collection of British Manuscripts, 1593/20151