- Mary A. Thompson Papers, 1893/19741
- Maury Family papers, 1777/19771
- Mills E. Godwin, Jr. Papers, 1712/1989, bulk 1947/19891
- Mr. and Mrs. James Hoover Collection of Strickler Family Papers, 1770/19631
- Office of the President: G. Tyler Miller Papers, 1941/19981
- Overton family papers, 1727/1961, bulk 1781/18751
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19741
- R. Harvey Chappell, Jr. Papers, 1950/19821
- Richard G. Joynt Collection of British Manuscripts, 1593/20151
- Richard Lee Morton papers, 1756/2006, bulk 1930/19691
- Roane Family Papers, 1880/1973, bulk 19501
- Robb-Bernard Papers, 1665/1980, bulk 1850/19501
- Rupp Family papers, 1831/19731
- Shenandoah Valley Legal Documents, 1751/1968, bulk 1901/19351
- Shields Family Papers, 1832/19901