- Campbell Family Papers II, 1795/19451
- Campbell Family Papers, 1726/19201
- Carter Braxton Collection, 1833/1922, bulk 1833/18371
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Chappelear Collection, 1788/19591
- Charles Brown Papers, 1792/18881
- Charles H. Bell Papers, 1772/1929, bulk 1852/18751
- Charles Triplett O'Ferrall Papers, 1856/1904, bulk 1867/18931
- Clarence P. Jones, Jr. Papers, 1773/1915, bulk 1809/18211
- Conway Whittle Papers, 1773/1911, bulk 1801/18671
- Cook-Luttrell Papers, 1848/18901
- Crump Family Financial Papers, 1848/18701
- Cushing Family Papers, 1843/18941
- Daniel Philippe Aunspaugh Papers, 1800/18811
- Daniel Stickley Papers, 1829/19121