- Charles Brown Papers, 1792/18881
- Charles H. Bell Papers, 1772/1929, bulk 1852/18751
- Clarence P. Jones, Jr. Papers, 1773/1915, bulk 1809/18211
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18391
- Conway Whittle Papers, 1773/1911, bulk 1801/18671
- David A. Bucher Papers, 1769/19121
- Davidson Family Papers, 1773/19381
- Dew Family papers, 1794/18951
- Fairfax Harrison Papers, 1736/19451
- Francis Little Collection, 1770/18641
- Francis P. Lee Papers, 1727/19301
- Galt Papers (III), 1750/19911
- Geddy-Harris Archive Records, 1773/1959, bulk 1890/19401
- George Wythe Collection, 1779/19271