- Baird Family Papers, 1656/1922, bulk 1656/18481
- Blair Family Papers, 1741/17921
- Brafferton Estate Collection, 1691/19351
- C. L. Worthington Papers, 1752/19381
- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Campbell Family Papers, 1726/19201
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18391
- Fairfax Harrison Papers, 1736/19451
- Francis P. Lee Papers, 1727/19301
- Galt Papers (III), 1750/19911
- Grigsby-Galt Papers, 1736/1982, bulk 1840/19301
- Harrisonburg-Rockingham Historical Society Collection, 1740/19501
- Historic manuscript collection, 1601/19331