- Manley Family papers, 1707/19531
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Mary and Hannah Gibbons Papers, 1743/18901
- Maupin-Washington Papers, 1732/19321
- Mills E. Godwin, Jr. Papers, 1712/1989, bulk 1947/19891
- Myron Schmall Collection, 1711/18151
- Office of the President. James Blair Records, 1695/17471
- Overton family papers, 1727/1961, bulk 1781/18751
- Richard Billups Papers, 1705/1857, bulk 1774/18221
- Richard G. Joynt Collection of British Manuscripts, 1593/20151
- Robb-Bernard Papers, 1665/1980, bulk 1850/19501
- Robert Morton Hughes Papers, 1715/1940, bulk 1871/19331
- Short Papers, 1675/17891
- Tucker-Coleman papers, 1664/1945, bulk 1770/19071
- Tyler Family Papers, Group A, 1716/19461