- Baird Family Papers, 1656/1922, bulk 1656/18481
- Brafferton Estate Collection, 1691/19351
- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Campbell Family Papers, 1726/19201
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18391
- Fairfax Harrison Papers, 1736/19451
- Francis P. Lee Papers, 1727/19301
- Grigsby-Galt Papers, 1736/1982, bulk 1840/19301
- John Dixon Papers, 1729/18291
- Manley Family papers, 1707/19531
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Maupin-Washington Papers, 1732/19321
- Mills E. Godwin, Jr. Papers, 1712/1989, bulk 1947/19891