- Baird Family Papers, 1656/1922, bulk 1656/18481
- Brafferton Estate Collection, 1691/19351
- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Collection of Spanish Language Manuscripts, 1551/18581
- Manley Family papers, 1707/19531
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Mills E. Godwin, Jr. Papers, 1712/1989, bulk 1947/19891
- Myron Schmall Collection, 1711/18151
- Office of the President. James Blair Records, 1695/17471
- Richard Billups Papers, 1705/1857, bulk 1774/18221
- Richard G. Joynt Collection of British Manuscripts, 1593/20151
- Robb-Bernard Papers, 1665/1980, bulk 1850/19501
- Robert Morton Hughes Papers, 1715/1940, bulk 1871/19331
- Short Papers, 1675/17891