- Andrew Summers Rowan (1857-1943) Papers and Memorabilia, 1940/19601
- Anita Buchanan Speers, Historian, Papers, 1916/19571
- Archibald Woods Papers, 1777/1846, bulk 1783/18461
- Bernard Humbles, Collector, Cherokee Treaties and Other Material, 19961
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Bradford Noyes (b.1860) Typed Document, 19481
- Brafferton School quilt, 20221
- Charles L. Campbell (b. 1876), Compiler, Typescripts, 1789/19561
- Cleaver Family Papers, 1777/19691
- David Ives Bushnell, Jr. Papers, 1797/19411
- Dr. William H. Waddell, Veterinarian and Author, Records, 1938/19871
- Elaine Bixiones collection, 1968/19691
- Frederick B. Lambert, Collector and Compiler, Papers, 1819/19591
- G. Harry Bayles Papers, 1890/19551
- Grigsby-Galt Papers, 1736/1982, bulk 1840/19301