- Baer Family Papers, 1744/19291
- Baird Family Papers, 1656/1922, bulk 1656/18481
- Bowman Family Papers, 1765/19981
- Chester McNerney Collection, 1290/19501
- Davis, Kline, and Hutton Family papers, 1816/19771
- Eldon Bowman collection of Bowman family papers, 1797/20191
- George Washington collection, 1775/19491
- Henkel Family Papers, 1783/18741
- John T. Harris papers, 1771/1937, bulk 1850/19001
- Legal Documents, 1742/18951
- Manley Family papers, 1707/19531
- Margaret Grattan Weaver collection, 1707/1992, bulk 1857/19101
- Marianne L. Garber Collection of Shenandoah Valley Documents, 1780/18991
- McCown Family Papers, 1811/19171
- Richard G. Joynt Collection of British Manuscripts, 1593/20151