- Black, Kent, and Apperson Family Papers, 1779/19841
- Brown Family Papers, 1825/1965, bulk 1850/18941
- Charles W. Hardin Collection, 1847/18831
- Elden E. Billings Collection, 1862/19911
- Guy Di Carlo, Jr., Civil War Research Papers, 1862/20021
- Isaac White Letters, 1861/19381
- James R. Perdue Family Collection, 1868/19191
- John Harville Diaries, 1861/2010, bulk 1861/18641
- Martha L. Johnson Family Papers, 1821/18821
- Meade & Baker Apothecary Ledger, 1861/18701
- Medical Bill Signed by Dr. Harvey Black, 1865/18791
- Robert Ellett Account Book, 1867/18731
- Southwest Virginia Counties Collection, 1824/18851
- Western Lunatic Asylum [Staunton, Virginia] Collection, 1840/1903, bulk 1840/18681