- Brown, Coalter, Tucker Papers (I), 1790/19291
- Brown, Coalter, Tucker Papers (II), 1791/19201
- Brown, Coalter, Tucker Papers (III), 1838/19641
- Buford Family Papers, 1845/18951
- Byers Family Papers, 1806/19291
- C. L. Worthington Papers, 1752/19381
- Calfee Family Papers, 1812/1919, bulk 1859/18891
- Campbell Family Papers II, 1795/19451
- Campbell Family Papers, 1726/19201
- Carpenter Papers, 1765/19221
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Charles Brown Papers, 1792/18881
- Charles D. Tibbetts Papers, 1848/19321
- Collection of Spanish Language Manuscripts, 1551/18581
- Cook-Luttrell Papers, 1848/18901