- Christopher Tompkins Papers, 1778/18381
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18391
- Connecticut Silk Industry Collection, 1786/17921
- Dunmore Family Papers (I) [in part photocopies], 1650/18991
- Earl Gregg Swem Genealogy Collection, 1719/19821
- Fairfax Harrison Papers, 1736/19451
- Francis Little Collection, 1770/18641
- Galt Papers (I), 1745/18921
- Galt Papers (III), 1750/19911
- George Frederick Holmes Papers, 1790/1898, bulk 1842/18871
- George Mason Papers, 1706/18581
- George Washington collection, 1654/17992
- Grigsby-Galt Papers, 1736/1982, bulk 1840/19301
- Henry Denison Cole Papers, 1786/19391