- Armistead-Cocke Papers, 1680/19171
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Brafferton Estate Collection, 1691/19351
- Campbell Family Papers, 1726/19201
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18391
- Dunmore Family Papers (I) [in part photocopies], 1650/18991
- Earl Gregg Swem Genealogy Collection, 1719/19821
- Fairfax Harrison Papers, 1736/19451
- George Mason Papers, 1706/18581
- Grigsby-Galt Papers, 1736/1982, bulk 1840/19301
- Historic manuscript collection, 1601/19331
- John Dixon Papers, 1729/18291
- John Garland Pollard Papers, 1683/1968, bulk 1856/19371