- Armistead-Cocke Papers, 1680/19171
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Brafferton Estate Collection, 1691/19351
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Collection of Spanish Language Manuscripts, 1551/18581
- Dunmore Family Papers (I) [in part photocopies], 1650/18991
- Earl Gregg Swem Genealogy Collection, 1719/19821
- George Mason Papers, 1706/18581
- John Garland Pollard Papers, 1683/1968, bulk 1856/19371
- Lexington Arsenal and Virginia Militia records, 1702/18392
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Richard Billups Papers, 1705/1857, bulk 1774/18221
- Robb-Bernard Papers, 1665/1980, bulk 1850/19501
- Thomas G. and Louise Rowe Pullen Collection, 1655/17911
- Tucker-Coleman papers, 1664/1945, bulk 1770/19071