- Barnhart Family Papers, 1836/19441
- Bushrod Washington family papers, 1662/18353
- Debra S. Clatterbuck Collection of Michael Henkle Estate Records, 18611
- Eldon Bowman collection of Bowman family papers, 1797/20191
- George Washington collection, 1654/17991
- Historic manuscript collection, 1601/193310
- John Augustine Washington III and Mount Vernon Ladies' Association (MVLA) collection, 1834/19571
- Liskey Collection of Heavner Family Papers, 1788/19671
- Michael Baker Estate Papers, 1810/18391
- Peter family papers, 1722/19321
- Ted and Mary Wendell early American collection, 1721/18262
- Warden and Harnsberger Family Papers, 1806/18801
- William and Verdie Lindamood papers, 1957/19831