- Alexander M. Davis Papers, 1850/18921
- Chappelear Collection, 1788/19591
- Charles Jackson Letter Books, 1890/19041
- Galt Papers (I), 1745/18921
- Hart collection, 1762/19391
- Henkel Family Papers, 1801/20081
- James Poyntz Nelson Manuscript Volumes, 1883/18941
- James Turner Clarke Daybook, 1854/19101
- Linville scrapbook and daybook, 1883/2013, bulk 1883/18931
- Morton Genealogy Collection, 1830/19781
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19742
- Rhodes & Speck Account Books, 1888/18931
- Robert H. and Lorraine Strickler Collection of John Zigler Daybooks, 1816/19031
- Scott and Gunnell family papers, 1772/19901
- Shenandoah Valley miscellaneous ledgers, minute books, and registers, 1804/19331