- Alexander Hamilton, Jr. Letters, 1832/18331
- Alfred Leyburn Papers, 1823/1899, bulk 1830/183915
- Blake W. Corson, Jr., Papers, 1861/1984, bulk 1934/19791
- Charles E. Kilbourne personal papers, 1898/19631
- Charlottesville Woolen Mills records, 1868/19561
- Effinger School Collection, 1909/20112
- Fix Family Papers, 1830/19241
- Historic manuscript collection, 1601/19333
- Jesse H. Heath, Jr. collection, 1941/19933
- John Alexander Graham Papers, 1910/1947, bulk 1915/19473
- John Augustine Washington III and family papers, 1789/19941
- John Randolph of Roanoke Collection, 1806/18321
- John T. L. Preston and Francis H. Smith correspondence, 18391
- John White Brockenbrough Papers, 1863/1874, bulk 1863/18741
- Office of Communications and Marketing subject files, 195020