- A. H. Hand Papers, 1835/20091
- A. L. McLeod Papers, 1964/19661
- A. Willis Robertson Papers, 1921/1988, bulk 1946/19661
- Abraham Anson papers, 1939/20051
- Agnes Wolf papers, 1966/20061
- Alexander Haight family collection, 1764/19761
- Alumni Association Records, 1833/2014, bulk 1950/20051
- Alvin Duke Chandler Papers, 1896/1984, bulk 1950/19601
- American Association of University Professors, College of William and Mary Chapter Records, 1924/1979, bulk 1924/19791
- American Public Transportation Association records, 1898/19991
- American Studies Program Records, 1960/20061
- Amos Koontz Papers II, 1865/19701
- Andrew C. L. Gatewood papers, 1860/19931
- Ann Buckles Papers, 1950/20081
- Anson Du Puy Van Buren letters, 1863/19971