- Blacksburg Baptist Church Records, 1894/20071
- Blake W. Corson, Jr., Papers, 1861/1984, bulk 1934/19792
- Dean Carter Papers, 1950/2003, bulk 1964/19821
- Duncan Alexander MacLeod Collection, 1932/19861
- Henry Clay Deshields Collection, 1861/20161
- J. T. Price Civil War Collection, 1862/19681
- John G. and Georgia (Skinnell) Atkins Correspondence, 1907/1986, bulk 1907/19111
- Morgan Goodhart Papers, 1933/19611
- Records of the Virginia Tech Board of Visitors, Guy L. Furr, 1949/19641
- Robert E. Marshak Papers, 1933/19951
- Shaver and Schaeffer Family Collection, 1872/19771
- Stephen Spender Papers, 1951/19631
- Tyler-Wilson Family Papers, 1899/19601
- Welford D. Taylor Collection on Sherwood Anderson, 1918/20061