- B. Floyd Flickinger Papers, 1927/19501
- Barron Family Papers, 1793/19421
- Beverley R. Tucker papers, 1886/19731
- Blacksburg Baptist Church Records, 1894/20071
- Blake T. Newton, Jr. Papers, 1939/19851
- Blake W. Corson, Jr., Papers, 1861/1984, bulk 1934/19792
- Bland Family papers, 1778/19891
- Blizzard Family Papers, 1929/1949, bulk 1942/19451
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Blue Ridge Springs Correspondence, 1895/19421
- Board of Visitors records, 1757/20231
- Borland Family Papers, 1771/19401
- Botts Family Correspondence, 1933/19461
- Bozarth Family Papers, 1931/1985, bulk 1931/19621
- Broome Family Papers, 1862/19951