- Blacksburg Baptist Church Records, 1894/20071
- Blake W. Corson, Jr., Papers, 1861/1984, bulk 1934/19791
- Blue Ridge Springs Correspondence, 1895/19421
- Duncan Alexander MacLeod Collection, 1932/19861
- Henry Clay Deshields Collection, 1861/20161
- J. T. Price Civil War Collection, 1862/19681
- John G. and Georgia (Skinnell) Atkins Correspondence, 1907/1986, bulk 1907/19111
- John Muse Correspondence, 1906/1951, bulk 1906/19071
- Mary Sinton Leitch Correspondence with J. J. Lankes, 1932/19501
- Morgan Goodhart Papers, 1933/19611
- Robert E. Marshak Papers, 1933/19951
- Russell Family Correspondence, 1927/19431
- Shaver and Schaeffer Family Collection, 1872/19771
- Turner Family Papers, 1830/19441
- Tyler-Wilson Family Papers, 1899/19601