- A. H. Hand Papers, 1835/20091
- A. K. Leake Papers, 1872/19401
- Addison Family Papers, 1890/18991
- Albert C. Swindler Papers, 1862/1929, bulk 1862/18641
- Alexander Brown Papers (I), 1815/19101
- Alexander Brown Papers (II), 1748/19001
- Alexander Farish Robertson Papers, 1867/19311
- Alexander Haight family collection, 1764/19761
- Alexander Hamilton, Jr. Letters, 1832/18331
- Alexander Lockhart Nelson papers, 1848/19021
- Alfred E. Bradley Papers, 1864/1922, bulk 1916/19181
- Alfred Leyburn Papers, 1823/1899, bulk 1830/18392
- Allen-Kean-Laurence family letters, 1837/19601
- Alumni Association Records, 1833/2014, bulk 1950/20051
- Alvin Duke Chandler Papers, 1896/1984, bulk 1950/19601